Archana V, Pushpalatha K, Udayakumar S, Hareesh Sanikam
Immune reconstitution inflammatory syndrome (IRIS) in a patient on anti-tubercular treatment (ATT) in the setting of antiretroviral therapy (ART) is well described, but it is not as common in non-HIV patients. Distinguishing this paradoxical reaction (PR) from disease progression or treatment failure is an important issue in CNS tuberculosis management. Thus one must keep a watch for neurological deterioration in a child with CNS TB. We are presenting a case series of three non HIV children who developed TB-IRIS while on anti-tubercular drugs, who subsequently responded to steroids along with continuation of ATT.
