Srinivas Prasad R. H1, B. V. Balakrishna2, Narendranath Kudva3, Sandhya H4, Ramakrishna P5
ABSTRACT: OBJECTIVE: To evaluate the prevalence of non-alcoholic fatty infiltration in women with PCOS. MATERIALS AND METHODS: A prospective study in which 162 women with Polycystic ovarian syndrome (PCOS) and 165 healthy controls who were age and weight matched were included. Anthropometric parameters evaluation, biochemical and hormonal investigations were done in all the patients with PCOS and controls. Insulin resistance was calculated by Homeostasis model assessment (HOMA). Per abdominal sonography and biochemical investigations were used to determine the presence of hepatic steatosis. Other causes for liver disease were also excluded. RESULTS: Women with PCOS had a higher prevalence of hepatic steatosis (68% vs 26%, P =0.001), MS (37% vs. 6%, P <0.01) and elevated transaminases (32% vs. 8%, P =0.03) than controls. All patients with PCOS and controls with Metabolic Syndrome (MS) had presence of hepatic steatosis. CONCLUSION: Non-alcoholic fatty infiltration is significantly seen in women with PCOS in combination with other metabolic derangements. Liver disease should be excluded by various investigations at an earlier age in women with PCOS, particularly those who have an evidence of MS.
