K. Padmamalini
Kimuraâ??s disease is a rare chronic inflammatory condition of unknown aetiology which has been most commonly reported in Asian population, with young male preponderance. It is a benign disease which has an indolent course & gradually increases in size over months or years. It primarily involves the head and neck region, presents as subcutaneous masses and is often accompanied by regional lymphadenopathy, salivary gland involvement along with lymphadenopathy or presents with only lymphadenopathy. Peripheral blood eosinophilia and elevated serum immunoglobulin E (IgE) levels are characteristic features. Microscopy reveals lymphoid proliferation with eosinophilic infiltration. For years, Kimuraâ??s disease was believed to be identical to or part of the same disease spectrum as angiolymphoid hyperplasia with eosinophilia (ALHE). Recent reports, however, have confirmed that the two are, in fact, separate entities.
