N. Senthil 1 , R. B. Sudagar Singh 2 , Sneha Thomas 3 , C. Sujeetha 4 , S. Sujatha 5 , J. Damodharan 6
this study is to assess the correlation of lipid profile and its ratio’s with insulin resistance and its predictability in identifying insulin resistance. METHODS: This is a cross sectional study of 100 obese patients without diabetes. Obesity was defined by Body mass index (BMI) greater than 30. Fasting blood was obtained for Lipid profile, Insulin and blood glucose. Post prandial blood was taken for blood glucose. HOMA-IR model was chosen for calculating insulin resistance. Results obtained were analysed by student’s t-test and Pearson’s correlation done for the same. RESULTS AND OBSERVATION: The data on analysis revealed triglycerides, triglyceride/hdl-c ratio, total cholesterol/hdl-c ratio and serum fasting insulin level were significantly higher in homa-ir>2.5 group with statistical significance, comparing with other group. CONCLUSION: Triglycerides, triglyceride/hdl-c and total cholesterol/hdl-c ratios can be used as a simple surrogate marker of insulin resistance in clinical setting in obese non diabetic individuals.
