Sonalee Sahu1 , Manas Ranjan Behera2 , Subhabrata Das3 , Asutosh Hotta4 , Swaraj Sambit Samal5
BACKGROUND Locally Advanced Breast Cancer (LABC) is a subset of breast cancers characterized by advanced breast tumours in the absence of distant metastasis. The need to identify LABC as a separate group of breast cancers arose in view of the high associated rate of locoregional and systemic failure. Management includes multimodality treatment which is complex. LABC is the most common mode of presentation in the region of study i.e. the southern part of Odisha. Aim is to study the multimodal treatment and its response as provided in this institution. METHODS This prospective study was conducted in the Postgraduate Department of General Surgery, M.K.C.G. Medical College & Hospital, Berhampur, Orissa, from July 2017 to June 2019 including 6 months of follow up period. 49 cases of locally advanced breast cancer were included in the study. Multimodal treatment including surgery and chemotherapy was offered. Response to surgery and various chemotherapeutic agents was evaluated. RESULTS Combination of neoadjuvant chemotherapy, modified radical mastectomy, adjuvant chemotherapy achieved superior locoregional control and delayed systemic dissemination. Maximum clinical response was seen in paclitaxel receivers i.e. complete response in 22 % and partial response in 77 % of cases with 0 no response rates. After 6 months of follow up of multimodal treatment of LABC, the overall survival rate is maximum in stage IIIA with 95.8 %, followed by 83.3 % in stage IIIB and 42.8 % in stage IIIC. CONCLUSIONS Surgery and chemotherapy are more effective in locally advanced breast cancer than surgery alone and paclitaxel as chemotherapy displays high level of antitumour activity.
