Prathima Raj Dara1, Rajendra Prasad Suram2, Md. Yousuf Khan3
BACKGROUND
Diabetes is treatable, yet not withstanding when glucose levels are under control. It significantly increase the risk of coronary illness and stroke. Especially, type 2 diabetes may have the accompanying conditions that add to their danger for creating cardiovascular illness, for example, hypertension, weight, and abdominal cholesterol. This study to investigate the risk of cardiovascular malady (CVD) in people with diabetes mellitus treated with metformin or other antidiabetic medications.
SUBJECTS AND METHODS This was an observational study conducted in the Department of Medicine at Government General Hospital, Nizamabad. 500 patients were aged between 60 and below individuals diagnosed with cardiovascular problem irrespective of metformin or other anti-diabetic drugs from past years. Patient’s comparison with previous use of metformin or other anti-diabetic drugs among the individuals and calculated the risk of cardiovascular disease who is on metformin or anti-diabetic drugs.
RESULTS
In comparison with metformin, long-term use of other than metformin were at greater risk of developing CVD (Adjusted OR (AOR)=0.83, 95% CI=1.12-2.60), but there was no consistent trend with increasing number of prescriptions. Long-term use of other antidiabetic drugs such as sulphonylurea (AOR=0.80, 95% CI=0.72-1.42), thiazolidinediones (AOR=0.69, 95% CI=0.31-2.40), or meglitinides (AOR=0.61, 95% CI=0.58-1.73) was showed related risk of developing CVD.
CONCLUSION
Long-term utilization of sulphonylurea, thiazolidinediones, or meglitinides was showed risk of developing CVD. There was a recommendation of a slightly bring down risk of CVD in long-term use of metformin.
