Sunil Vitthalrao Jagtap1, Atul Abhimanyu Beniwal2, Heena Pradeep Shah3, Suresh Jaywantrao Bhosale4, Pandurang G. Chougule5, Swati Sunil Jagtap6
AIM AND OBJECTIVES
To study the clinical and histopathological features of medullary breast carcinoma (MBC) in rural population in Western Maharashtra.
MATERIALS AND METHODS
This is a retrospective, analytic study which is done at a tertiary care hospital from March 2010 to April 2016 for a period of 6 years.
RESULTS
Total of 241 consecutive cases of breast malignancy surgically operated for mastectomy or modified radical mastectomy were studied. From these 241 cases, 11 were reported as medullary carcinoma (constitute 4.56%). From these 11 cases, 10 cases were of typical medullary breast while 1 case was of atypical medullary breast carcinoma was noted. Each case was studied for clinical, morphological, radiological and immunohistochemistry (IHC) findings. For typical medullary carcinoma, the age range in present study was 33 to 55 years with a mean age of 46.3 years. The common clinical presentation was painless lump in the breast with common location being upper outer quadrant. The size of the tumour ranged from 2.5 to 9 cm with a mean size of 5.6 cm. The axillary lymph nodes were involved in 4 (40%) cases. The ER, PR and HER-2 were found to be positive in 10%, 10% and 20% respectively. Triple negative cases were 70%.
CONCLUSION
The clinicopathological features of medullary breast carcinoma showed early disease stage, having high-grade histological features of tumour, more triple negativity for ER/PR/HER2 and low rate of nodal metastasis.
