Pulok Kutum1 , Rajesh Singh Laishram2 , Khuraijam Anupama Devi 3 , Mohd. Yunus Ali 4 , Tulsi Rani Chanamthabam5 , Prasenjit Das 6 , Sultana Parveen
BACKGROUND
Thrombocytopenia defined as platelet counts less than 1,50,000/μL is commonly found in many haematological practices. The
various disorders ranges from benign to malignant conditions.
MATERIALS AND METHODS
All the bone marrow aspiration smears who presented with thrombocytopenia were retrospectively studied during the period
May 2015 to April 2017. The study was conducted in the Department of Pathology, Regional Institute of Medical Sciences,
Imphal. All the Leishman stained bone marrow aspirate smears were taken from the archives and studied again with special
reference to the megakaryocyte number and the various morphology. The clinical details and the diagnosis were also noted.
RESULTS
A total of 258 bone marrow aspiration smears were included in the study. The most common cause of thrombocytopenia in the
study was AML (53 cases), followed by nutritional anaemia (42 cases) and hypoplastic anaemia (38 cases). Various other causes
like aplastic anaemia, infective cause and malignant infiltration of the bone marrow were also encountered. In cases of
myelodysplasia, dysplastic forms, bare megakaryocytic nuclei, hypogranular forms and micromegakaryocytes were seen.
CONCLUSION
Giving an undue importance to the morphology and number of megakaryocytes, while reporting bone marrow aspiration smears
can help in enabling the diagnostic accuracy of various haematological conditions.
