Poonam Nanwani
Megaloblastic anaemia is a nutritional anaemia that results from inhibition of DNA synthesis during red blood cell production. Thrombocytopenia in a case of megaloblastic anaemia may result from many mechanisms such as: marrow hypoplasia (decreased megakaryocytes), ineffective thrombopoiesis (normal to increased megakaryocytes) and increased destruction of platelets (increased megakaryocytes). The objectives of this study were- 1. to correlate clinicohaematological features in megaloblastic anaemia and bone marrow aspiration study of thrombocytopenia secondary to megaloblastic anaemia, hypoproduction and hyper-destruction 2. to understand the various megakaryocytic alterations in haematological disorders presenting with thrombocytopenia due to different mechanisms.
