Sunil Vitthalrao Jagtap1, Atul Abhimanyu Beniwal2, Heena Pradeep Shah3, Swati Sunil Jagtap4, Pandurang G. Chougule5
INTRODUCTION
Metaplastic carcinoma of the breast (MCB) denotes a heterogeneous group of rare malignant tumour of the breast expressing epithelial and/or mesenchymal tissue within the same tumour.
AIMS
To evaluate the clinicopathological features of 11 cases of metaplastic breast carcinoma in surgically excised malignant breast tumours in 8 years from April 2008 to March 2016.
MATERIALS AND METHODS
Total 284 consecutive cases of malignant breast lumps were removed surgically during study period, out of which 11 cases were diagnosed to have metaplastic breast carcinoma and were studied for its clinical features, size, site, gross morphological features, histopathological diagnosis, ER, PR, HER2 status, lymph node status.
OBSERVATIONS
Out of total 11 cases, 4 cases showed epithelial (tumour expressing adenocarcinoma and squamous cell carcinoma or squamous cell carcinoma alone), 6 cases showed biphasic (tumour expressing carcinoma and sarcomatoid or spindle cell component) and 1 case showed monophasic (tumour exclusively of sarcomatoid or spindle cell component). The mean age of the patient was 44 years, 8 cases were triple ER/PR/HER2 negative. Largest tumour size was 16 cm with mean size of 7 cm. Only 3 cases showed lymph node metastasis on histopathology.
CONCLUSION
In our study of metaplastic breast carcinoma, patients were found to be younger–mean age 44 years, as compared with other studies of metaplastic breast carcinomas. Clinically, they had bigger size of tumour–mean 7 cm, at presentation, aggressive course with low regional lymph node metastasis-27.3%. Most of these cases were triple negative (72.7%) for ER, PR and HER2 on immunohistochemical study.
