Aakassh Sreedharan1, Nayyar Iqbal2, Sudhagar Mookkappan3
BACKGROUND
Metabolic syndrome is an important risk factor for cardiovascular disease and type 2 diabetes mellitus. According to International Diabetes Federation, the risk factor associated with metabolic syndrome are central obesity, hypertension, increased fasting glucose, triglyceride level and decreased HDL. Recent studies also found that hyperuricaemia is also associated with insulin resistance and increased cardiovascular disease related morbidity. A cross-sectional study was conducted at Pondicherry Institute of Medical Sciences with an objective to find the prevalence of hyperuricaemia among patients with metabolic syndrome and also to find the association of risk factor of metabolic syndrome with serum uric acid level.
MATERIALS AND METHODS
103 patients (49 males and 54 females) who fulfilled the inclusion criteria were included in the study. Detailed medical history and physical examination including height, weight, BMI, waist circumference and blood pressure were recorded. Five millilitre of fasting blood sample was taken for lipid profile, serum uric acid and fasting blood glucose. Chi-square test was done to find out the association between metabolic syndrome and risk factors of hyperuricaemia with ‘p’ value of <0.05 were considered statistically significant. Pearson’s correlation was used to assess correlation between variables. Univariate logistic regression was used to calculate regression coefficients and Odd’s ratio for risk factors.
RESULTS
Out of 103 participants, 49 were males and 54 were females with mean age of 56.71 ± 11.015 and 54.98 ± 9.78, respectively. The prevalence of hyperuricaemia among males and females were found to be 18.36% and 14.81%, respectively, with overall prevalence of 16.5%. Hyperuricaemia was associated with increased age in males, but not in females. Age, BMI, diastolic blood pressure had very weak positive correlation with hyperuricaemia in both male and female, although they were not statistically significant (p >0.05). Exercise had negative influence on uric acid level in both gender, 41% less in males and 14% less in females. Diet also had positive influence on uric acid levels in both male and female.
CONCLUSION
The prevalence of hyperuricaemia among males is higher than females. The risk factors of metabolic syndrome like obesity, hypertension and increased cholesterol level are associated with hyperuricaemia.
