Pradeep Narayanan1, Narendran Ambedkar2, Prakash Senthaizhselvan3, Sabu Augustine4
BACKGROUND
Sepsis is a potentially life threatening medical emergency. It should be diagnosed
at the earliest and treated effectively to prevent mortality. Therefore, there is a
need for parameters which are simple, reliable and cost effective which help in
predicting the prognosis and help in managing the patient with sepsis more
efficaciously.
METHODS
A total of seventy patients, 42 male and 28 female patients, over a period of one
year, who fulfilled the inclusion and exclusion criteria was included in the study.
In this study various clinical variables and biochemical markers including serum
lactate dehydrogenase (LDH) were compared among survivor and non–survivor
groups and analysed.
RESULTS
In this study out of 70 patients, 36 patients [51.4 %] expired. Various clinical
variables and biochemical markers including serum LDH [on day 1 & day 3], were
compared among survivor and non–survivor groups and analysed. Pulse rate,
mean arterial pressure (MAP), total leucocyte count, renal function test (RFT), liver
function test (LFT), day 3 LDH levels and requirement of ventilator support showed
statistically significant difference among the survivor and non-survivor groups.
CONCLUSIONS
Despite the recent medical advances, sepsis is a multiorgan disease with
significant mortality. Hence, we need simple and effective parameters which are
essential in assessing the prognosis and in guiding the treatment protocols. This
study focused on simple clinical and biochemical parameters with special reference
to LDH, which helped us in predicting the mortality.
