Kumar Prafull Chandra1, Anil Kumar Pawah2, Dhirendra Kumar Shukla3
BACKGROUND
Abnormality in lipid and thyroid function is commonly observed in patients with type 2 diabetes mellitus. Both hypothyroidism and hyperthyroidism are the reasons to develop secondary dyslipidaemia.
The aim of the study is to study the thyroid function and its correlation with the lipid parameters in patients with diabetes and hypertensive diabetics.
MATERIALS AND METHODS
A prospective study was done on 141 diabetic patients in the Department of Medicine, Mayo Institute of Medical Sciences, Barabanki, between February 2016 to June 2016. All patients were divided into Group D (n=42, patients having diabetes only) and Group HD (n=99, patients having diabetes with hypertension). Detailed demographic parameters, glycaemic parameters including Fasting Plasma Glucose (FPG), Postprandial Glucose (PPG), HbA1c and average blood glucose were estimated. Thyroid function test viz. T3, T4 and TSH along with lipid parameters were estimated for all the patients.
RESULTS
Out of 141 patients, 29.78% were having diabetes alone, whereas 70.21% were having hypertension with diabetes. There were 80.95% males in patients with diabetes, whereas there were 76.76% males among hypertensive diabetics. All the demographic, glycaemic and lipid parameters were comparable between both the groups except age (p=0.0001), HbA1c (p=0.001) and average blood glucose (p=0.023). Thyroid function test was also comparable between both the groups, but correlation of lipid parameters with the thyroid function test parameters has revealed that LDL-C was significantly positively correlated with T3 (r=0.303, p=0.0004), T4 (r=0.181, p=0.036) and TSH (r=0.184, p=0.034). VLDL-C was also significantly positively correlated with the T3 (r=0.201, p=0.021).
CONCLUSION
Positive correlation was obtained between LDL-C and T3, T4 and TSH and VLDL-C with T3, which highlight the importance of screening thyroid function among diabetes patients with or without hypertension.
