Satyajeet K. Pawar1, P. M. Mane2, Ravindra V. Shinde3, H. V. Patil4, S. R. Patil5, G. S. Karande6, S. T. Mohite7
ABSTRACT: BACKGROUND: Pseudomonas aeruginosa is one of the leading causes of nosocomial as well as community acquired infections. Due to development of multi drug resistance (MDR), there are many therapeutic failures. The present study was carried out to find out the susceptibility pattern of the organism in this area. METHODOLOGY: From 2089 clinical specimens received over a period of six months, a total of 277 P.aeruginosa strains were identified and minimum inhibitory concentrations for various antibiotics was found out with help of automated method VITEK 2 (Biomerieux), RESULT: 75.81% P.aeruginosa isolated were MDR. Proportion of resistant strains varied from 38% to 75% to commonly used antipseudomonal antimicrobials groups like aminoglycosides, cephalosporins, carbapenems, fluoroquinolones, and anti-pseudomonal penicillins. Resistance to colistin was only15%. CONCLUSION: P. aeruginosa were less resistant to β lactam with β lactamase inhibitor combination therapy like cefoperazone /sulbactam and piperacillin/tazobactam. Colistin was most sensitive antibiotic. Prior information of susceptibility will be useful to reduce mortality and morbidity caused by P.aeruginosa.
