G. Rajendra 1 , P. V. Shiva 2 , B. Deepraj Singh 3 , Mohana Murali 4
ABSTRACT: The aim of the study is to compare the efficacy of intravenously administered 5-HT3 receptor antagonists namely Ondansetron, Palonosetron and Granisetron given as prophylaxis for postoperative nausea and vomiting in patients undergoing laparoscopic surgeries under general anaesthesia. A single dose of palonosetron (0.75 µg) when given prophylactically results in a significantly lower incidence of PONV after laparoscopic surgeries than ondansetron (4mg) and granisetron (2.5mg) during the first 24 hours
