Jojo Vattappalllil Joseph, Mebin Baby Thomas, Jincy Mathew
BACKGROUND 5% of all ovarian cancers are granulosa cell tumour. However, they are the most common subtype of ovarian sex-cord tumours (70%). They usually occur in young women and are usually detected at an early stage. The aim of this study was to report the clinical characteristics of GCT patients and to identify the recurrence rate. MATERIALS AND METHODS All cases of GCTs, treated at Caritas Cancer Institute between 2003 and 2007, were retrospectively included. Kaplan-Meier’s statistical method was used to assess the relapse-free survival and the overall survival. RESULTS 20 patients with GCT were included in the study. The mean age was 56 years (36-76 years). Patients mainly presented with abdominal mass and/or pain. Mean tumour size was 20 cms. The majority of patients had a stage I disease. Two out of three patients with stage IV disease had liver metastasis. Stage I disease and low-to-intermediate mitotic index were associated with a better prognosis in univariate analysis but were not independent prognostic factors. CONCLUSION This tumour has long natural history and late relapses. That’s why a long active follow-up is recommended. In Indian patients, hepatic metastases were more frequent than other series. The prognosis remains good and ideal cytoreduction is an important prognostic factor.
