1Associate Professor, Department of Biochemistry, Katihar Medical College.
INTRODUCTION Magnesium deficiency has been associated with Insulin Resistance (IR) and increased risk for type 2 diabetes in adults. We evaluated the relationship between magnesium and insulin resistance in obese diabetic woman visiting to medical outpatient clinics (OPD).
METHODS
In this cross-sectional study, a total of fifty diabetic female subjects with age group of 30-60 years, whose body mass index was above 30kg/m2 were studied for 16 months between July 2013 to November 2014 who were attending general medicine OPD were studied. Subjects with endocrine disorders other than diabetes or who were taking multivitamin supplements or corticosteroids were excluded. Blood samples were assessed for Serum magnesium, Fasting blood sugar, Fasting Insulin and HOMA IR was calculated.
RESULTS A total of fifty subjects participated in the study. The mean age of the patients was 31.4±7.32 years. We found that 43/50(86%) of these subjects are having insulin resistance as estimated by HOMA IR and 37/50(74%) are having hypomagnesaemia. Serum magnesium was inversely correlated with HOMA-IR (spearman r−0.44, P<0.05).
CONCLUSION
In our study, we observed that hypomagnesaemia coexists with insulin resistance in obese diabetics with insulin resistance. Caution has to be executed in interpretation of results as our sample is small. Serum magnesium deficiency in obese children may be secondary to decreased dietary magnesium intake.
