Kamal Singh1 , Jaspreet Kaur2 , Jasprabh Karanjit Kaur3 , Mehak Trehan4
Primary Biliary Cholangitis (PBC) is rare, with a low prevalence of 19 to 402 cases per million persons.1,2 Middle age women constitute about 90-95 percent of such rare disorders. Antimitochondrial antibodies (AMA) are the serological hallmark of PBC, present in approximately 95 percent of patients with PBC. There are very few case reports and case series of AMA-negative PBC in literature and this entity occurring in an Asian male patient makes it rarest. We report such a case of AMA and ANA negative PBC in middle age male subsequently diagnosed by histopathology.
