Sudipta Chakraborty1, Rina Kumari2, Niru Chhetri3, Arati Mukherjee4, Gorachand Bhattacharya5, Ila Bhattacharjee6
BACKGROUND Frequent haemodialysis is required for the patients with End-Stage Renal Disease (ESRD) to maintain non-toxic levels of serum urea and creatinine. During haemodialysis, increase in 24-hour ambulatory systolic blood pressure (SBP), diastolic blood pressure and blood pressure (BP) load was observed by researchers and that has been explained as high sodium concentration in dialysis solution. Post-dialysis increase in serum alkaline phosphatase level has been reported and this is associated with higher risk of hospitalisation and death.
AIMS AND OBJECTIVES Since very little information is available from study on Indian population, our aim was to determine pre and post-dialysis serum alkaline phosphatase and sodium concentrations in subjects of ESRD attending Medicine department of the hospital for haemodialysis at regular intervals with an object to compare our results with available reports from different sources
. MATERIALS AND METHODS The study was conducted in a tertiary care teaching hospital in eastern India by selecting 33 patients suffering from ESRD and they attended the dialysis unit of the hospital for undergoing haemodialysis. Serum sodium, potassium, urea, creatinine and alkaline phosphatase levels were measured. RESULTS Post-dialysis serum urea and creatinine values were lower than pre-dialysis result (p value < 0.001 and < 0.001 respectively). Significant decrease was observed in post-dialysis serum potassium level (p value < 0.001). Increase in serum sodium and alkaline phosphatase levels were observed in post-dialysis subjects (p value < 0.004 and < 0.001 respectively).
CONCLUSION In the study, we observed a significant increase in serum sodium and alkaline phosphatase concentrations in patients of ESRD after haemodialysis.
