Bilal Bin Abdullah, Nida Nausheen , Khalid Mazhar Mehdi , T. S. Mohammed Mustafa, Chirajit Sengupta
BACKGROUND Diabetes mellitus (DM) is a syndrome characterized by chronic hyperglycaemia and disturbances of carbohydrate, fat, and protein metabolism associated with absolute or relative deficiencies in insulin secretion and/or insulin action. Worldwide, approximately 200 million people currently have type II diabetes mellitus (DM), a prevalence that has been predicted to increase to 366 million by 2030. MATERIALS AND METHODS All participants are selected from those who visited Diabetes Clinic, in Al-Ameen Medical College Hospital and District Hospital, Bijapur between Dec 2013 - June 2015. 50 patients presenting with type 2 diabetes mellitus in middle age are included in the study. In our study, diabetic patients with cardiovascular complications had poor glycaemic status compared to diabetic patient without cardiovascular complications. RESULTS The results of this study confirm the hypothesis that hyperhomocysteinaemia is a risk factor for endothelial dysfunction and vascular diseases such as atherosclerosis and occlusive vascular disorders. CONCLUSION The homocysteine levels were comparatively more elevated in patients of diabetes with cardiovascular complications than the patients of diabetes alone, thus indicating that hyperhomocysteinaemia is an independent risk factor for CVD incidence in type 2 diabetic patients in middle age individuals.
