Nihar Ranjan Dash, Biswajit Mohanty
OBJECTIVES: The study was carried out for creating a profile in cases of hemoglobinopathies coming to our Hospital and comparing the results with other Indian studies. SETTING: The study was carried out at a premier tertiary care center in Orissa. A total of 820 referred cases of Anemia were examined between March 2010 to July 2015. METHODS: Hematological indices and hemoglobin HPLC with quantification of the bands was done in all cases. Hematological indices were measured on SYSMEX Cell Counter (XT-1800i) and Hemoglobin HPLC was performed on BIORAD D10. RESULTS: Out of 820 referred cases 453 was found to be normal and 367 had one or other form of haemoglobinopathy. The data shows the prevalence of Sickle cell Trait to be 18.6%, β Thalassemia -Trait 10.8% & Sickle cell disease 8.7% in the study population. CONCLUSIONS: The prevalence of hemoglobinopathy is found to be very high. It is present in a proportion of 1:2.25 in patients coming for anemia for investigation or clinically suspected cases of hemoglobinopathies. Hence, all the cases of anemia should undergo HPLC screening in this part of the country. There should be an initiative towards population screening, genetic counseling and prenatal diagnosis to counter the magnitude of problem.
