Manoj Gupta
BACKGROUND Sickle cell disease is a prevalent and a widely distributed disease in India. It has been found to be associated with multiple complications such as vaso-occlusion and painful crisis. The aim of the study is to assess the status of vitamin D deficiency amongst adult SCD patients. MATERIALS AND METHODS A cross sectional study with appropriate control group was conducted amongst the patients of MY Hospital, Indore. The Sample included 50 cases and 50 controls. Selection of cases was done on the predefined criteria. The cases and controls were selected based on inclusion and exclusion criteria. The participants who consent to participate were included in the study. The information related to clinical, biochemical parameters were obtained from both the groups. Statistical analysis was done using SPSS software. The comparison between the groups was done using Man Whitney U test, Chi square test and correlation was obtained using Spearmanâ??s correlation coefficient. RESULTS Results of the study showed presence of vitamin D insufficiency and deficiency amongst 92% of cases. The level of vitamin D showed significant correlation with frequency of painful crisis, blood transfusion and hospitalization. CONCLUSION It can be concluded that level of vitamin D decreases in SCD patients which can lead to complications such as painful crisis. So, vitamin D supplements can be given to such population to improve the condition of SCD patients.
