B. N. Kalpana1, Mohammed Sadiqulla2
PURPOSE: To study the occurrence of sterile endophthalmitis in patients undergoing intravitreal Bevacizumab for various indications.
METHODS: A retrospective analysis of case records of patients who developed intense anterior and posterior segment reaction after intravitreal bevacizumab was done in detail.
RESULTS: Six of the twenty six patients (23%) developed sterile endophthalmitis. There was no growth in repeated culture of aqueous or vitreous samples. All patients showed precipitation of drug in vitreous with resolution of symptoms after 8 weeks of intensive steroid treatment.
CONCLUSION: Intravitreal bevacizumab can cause sterile endophthalmitis though it is a diagnosis of exclusion. In view of many complications a larger clinical trial of intra vitreal bevacizumab is the need of the hour to justify its use.
