Swayamprava Pradhan 1 , Chandan Bajad 2 , Debi Prasad Mishra 3 , Anusuya Dash 4 , Sulata Chowdhary 5 , Samir Kumar Behera 6 , Manoj Kumar Patro 7 , Atanu Kumar Bal
BACKGROUND Breast carcinoma is the most common non-skin malignancy in women. More recently, it has been suggested that extracellular proteinase regulates growth factors and cytokines that might contribute to tumour progression. Since CD10 is a cell surface metalloproteinase which inactivates various biologically active peptides, it might facilitate cancer cell invasion and/or metastasis. MATERIALS AND METHODS 48 cases of Invasive Breast Carcinomas were taken up for the study along with 5 cases of benign tumour as a control group (fibro adenoma and phyllodes). Statistical Analysis: For all statistical data chi-square test was applied using IBM SPSS Statistics 20. RESULTS CD10 was found to be positive in 89% (n=43) cases of which 30.3% (n=13) cases showed weak immunoreactivity whereas strong immunoreactivity was observed in 69.7% (n=30) cases. Stromal CD10 expression correlated with well-established prognostic markers, i.e. higher tumour grade (P<0.001), lymph node metastasis (P=0.003), high mitotic rate (P=0.002), increasing NPI (P=0.003), ER negativity (P=0.032), PR negativity (P=0.041) and HER2/neu positivity (P=0.849). CONCLUSION Stromal CD10 expression in Invasive breast carcinomas is closely correlated with invasion and metastasis and it might play an important role in the pathogenesis.
