Rasheed Khan M.1, Thivyah Prabha A.G.2, Siva Kumar K.3
BACKGROUND
Mineral metabolism is frequently disturbed in thyroid dysfunctions. Among thyroid
dysfunctions, hypothyroidism is one of the most common form resulting from the
deficiency of thyroid hormones. Studies done on serum calcium, phosphorus and
magnesium in hypothyroid patients earlier have conflicting results. Hence the
present study has been undertaken to study the levels of serum calcium,
phosphorus, and magnesium among hypothyroid patients and analyse their
correlation with thyroid stimulating hormone (TSH).
METHODS
The case control study was conducted in the Department of Biochemistry in Trichy
SRM Medical College Hospital and Research Centre for a period of 6 months
from 2017 January to July 2017. The study was undertaken involving 50
hypothyroid cases and 50 healthy volunteers as controls after proper ethical
clearance and informed consent of all the study subjects. Serum calcium,
phosphorus and magnesium were measured along with tri-iodothyronine (FT3),
tetra-iodothyronine (FT4) and TSH among all study subjects. Statistical analysis of
data was done using statistical package for social sciences (SPSS) software.
RESULTS
The mean value of serum total calcium and total magnesium was lower among
hypothyroid cases and phosphorus value was increased as compared to controls.
(P < 0.001) Statistically significant negative correlation was observed between
serum calcium, magnesium and TSH among hypothyroid cases. Statistically
significant positive correlation was observed between serum phosphorus and TSH
among hypothyroid cases.
CONCLUSIONS
Among hypothyroid patients the values of serum calcium, magnesium and
phosphorus is significantly altered. Thyroid disorders have an important role in
bone and mineral metabolism. Thus, monitoring of these minerals among
hypothyroid patients in regular follow up may effectively improve the clinical
manifestations in them. Hence, monitoring of mineral status of the hypothyroid
patients on follow-up will be of benefit to the patients.
