Study of Correlation between Neuroimaging & EEG Changes in Seizure Disorder in Children (Six Months to Twelve Years)

Abstract

Runa Das1 , Ananya Mondal2 , Md. Azharul Islam3 , Sudipta Basu4 , Raman Sau4 , Rajatsubhra Haldar6 , Priyadarshini Sur7 , Sudhish Hazra8

BACKGROUND A seizure arises when a large number of neurons send out an electrical charge simultaneously, causing an abnormal intense wave of electricity. The present study aims to determine the frequency of abnormal neuroimaging in children with new onset seizures and to draw a correlation between clinical findings, electroencephalogram (EEG) findings and neuroimaging. METHODS This is a cross-sectional descriptive study conducted in the Department of Radiodiagnosis, Burdwan Medical College & Hospital. The entire study included recruitment of 160 subjects, data collection, data analysis, and reporting. An EEG was performed, using 18-channel EEG machine, within the first 48 hours of the first unprovoked epileptic seizure. RESULTS Partial seizure was seen in 54 (33.7%) children; complex febrile seizure in 18 (11.3%) children; and undetermined seizure in 6 (3.7%) children. Among cases of 6-12 years age group i.e. 94 (58.7%) cases, generalised seizure was found in 44 (27.5%) children; followed by partial seizure in 42 (26.2%); complex febrile seizure in 6 (3.8%); and undetermined seizure in 2 (1.2%) cases. Abnormal MRI was found in 120 (75%) cases; among them 64 (40%) cases were of generalised seizure; 44 (27.5%) partial seizures; followed by 9 (5.6%) and 3 (1.9%) cases of complex febrile seizure and undetermined seizure respectively. CONCLUSIONS 93 cases showed abnormalities in EEG findings, 111 in Computed Tomography (CT) findings, and 120 cases showed abnormality in Magnetic Resonance Imaging (MRI) findings, highlighting the superiority of MRI over CT and EEG.

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