U. Sreenivasulu 1 , S. N. Bhagyamma 2 , R. Anuradha 3
ABSTRACT: INTRODUCTION: Chronic renal failure (CRF) is decrease in glomerular filtration rate (GFR) to <60 ml/min/1.73 m2 for >3 consecutive months with multiple etiologies. CRF results in profound lipid disorder which stems largely from dysregulation of high density lipoproteins (HDL) & triglyceride-rich lipoprotein metabolism. Many a time CRF patients live on hemodialysis on regular basis. Present study was done to know whether hemodialysis has any impact on the lipid profile of the CRF patients. MATERIALS AND METHODS: Study were divided into 7 groups, Group-1: healthy controls (40), Group-2: CRF patients who never undergone hemodialysis (40), Group-3: CRF patients on hemodialysis (40), Group-4: Healthy males (28), Group-5: Healthy females (12), Group-6: males with chronic renal failure (28), Group-7: females with chronic renal failure (12). Sample analysed for high density lipoproteins (HDL), low density lipoproteins (LDL) & very low density lipoproteins (VLDL). RESULTS: Among the various parameters tested triglyceride and VLDL levels were significantly higher in group-2 and3 as compared to controls (p<0.0001). HDL levels were significantly lower in group-2 compared to Group-1(p <0.0001). HDL level was found reduced in group-3 as compare to Group-2(p=0.0035). There was no significant change (p=0.132) observed in total cholesterol between healthy controls and CRF patients with hemodialysis. There is a significant change (p=0.0309) observed in LDL-c between CRF patients and controls and no significant change observed (P=0.6070) between Group-2 and Group-3. CONCLUSION: CRF patients are at risk of cardiovascular diseases due to the elevation of various forms of lipids. Prescribing lipid lowering treatment in CRF patients with dyslipidemias for preventing future episode of cardiovascular events and will also preserve renal function
