Santhosh Kumar Thulaseedharan Saraswathy
BACKGROUND
Aims and Objectives
To study the clinical profile of patients with sepsis admitted to the medical intensive care unit.
To study the significance of SOFA score calculation of patients with sepsis to the outcome.
To ascertain the prognostic significance of repeated measurement of the SOFA score to refine outcome prediction in such patients.
MATERIALS AND METHODS
The study was conducted in 152 patients admitted with sepsis in the Medical Intensive Care Unit of Department of General Medicine, Govt. Medical College Hospital, Thiruvananthapuram. These patients were enrolled consecutively in the study and SOFA scores were calculated at zero hour and after 48 hours of admission to MICU, and followed till discharge/otherwise from the hospital.
RESULTS
Among the 152 cases, 51 patients expired showing the overall mortality of 33.6%. The maximum mortality was in 30 to 49 years age group (42.9%) followed by 50-69 years age group (34.5%), mortality among those with age >70 was 21.4% (This disparity may be because most number of patients entered in our study were of 30-69 years of age i.e. 121 patients). There was no significant statistical difference between the age in recovered patients and the expired. In this study, age has no correlation to outcome (i.e., death/discharge). The total number of death cases was more among males but there was no statistical difference between males and females (34.1% & 32.8%).
CONCLUSION
SOFA score at admission, delta SOFA score and repeat SOFA score at 48 hours are strong and independent predictors of mortality in sepsis patients. Average SOFA score of 8.5 at admission and 14.5 at 48 hours has 99% specificity for mortality prediction. Incidence of sepsis in MICU was 69.72%.
