Sanket Patil Gavigatt, Shivanna Poorna Prasad
BACKGROUND: Hyponatremia is the most common electrolyte disorder in hospitalized patients in diverse clinical settings. In fact, the neurohormonal activation that accompanies acute myocardial infarction is similar to that which accompanies heart failure. Hence, we aimed to investigate the prognostic importance of hyponatremia in the setting of acute ST elevation MI with reduced ejection fraction and to determine its usefulness in predicting short term survival.
METHODS: We used a prospective database consisting of all admissions of patients with acute ST-elevation. Qualifying patients underwent detailed history and clinical examination. The primary end point was all cause mortality within 30 days following myocardial infarction.
RESULTS: The odd‘s ratio for 30-day mortality was found to be high in hyponatraemic groups with reduced ejection fraction compared to normonatraemic group as well normal ejection fraction with hyponatraemia. Multivariate analysis was done which identified hyponatremia on admission or early development of hyponatremia in STEMI with reduced ejection fraction as a significant independent predictor of 30-day mortality.
CONCLUSION: In our study we concluded that hyponatremia on admission or early development of hyponatremia in patients with acute ST elevation myocardial infarction with reduced ejection fraction is an independent predictor of 30-day mortality.
