Jaskiran Kaur1, Gurinder Mohan2, Manish Chandey3
BACKGROUND
Cirrhosis of liver and its extrahepatic manifestations like hepatic osteodystrophy has
been linked to vitamin D deficiency, and has been proposed as a potential
therapeutic target. Its metabolism to 25-hydroxylation, makes liver necessary for its
activation. In this study sources of vitamin D, functions and its metabolism with a
focus on its variation with severity of liver cirrhosis is discussed.
METHODS
This is an observational study conducted on 60 patients with liver cirrhosis. The
severity of liver cirrhosis was assessed according to the Modified CPS. By technique
of enhanced chemiluminscence values of vitamin D were obtained. The results
were statistically analyzed using SPSS Statistics-20.0 version. Association among
different variables were calculated using Chi-Square Test and One Way ANOVA.
Results were considered significant if p value obtained was below 0.05 and highly
significant if it was below 0.001.
RESULTS
Mean age group of study population was 54.83 ± 13.56 years. 27 patients had
Alcoholic cirrhosis, 11 patients were HCV positive, 2 patients were HBsAg positive
and 20 patients had cirrhosis due to other etiologies. Mean vitamin D level of the
study population was 35.34 ± 22.4. 27 patients (45 %) had sufficient vitamin D,
18 patients (30 %) were deficient and 14 patients had insufficient vitamin D levels.
1 patient had vitamin D toxicity. There was no significant correlation between
mean vitamin D and etiology of liver cirrhosis (P value = 0.457; Not Significant).
There was significant correlation between vitamin D levels with severity of liver
disease (p value < 0.001).
CONCLUSIONS
In conclusion, low concentrations of 25 (OH) D are correlated with severity of liver
dysfunction irrespective of the etiology.
