Manoj Gupta1, Atul Shende2, Rajan Kumar Ahirwar3
BACKGROUND
The aim of this study is to explore and assess the relationship of elevated pulse pressure with haemolysis, proteinuria and chronic kidney disease in sickle cell disease (SCD) persons.
MATERIALS AND METHODS
This was a cross-sectional study. About 102 patients who were admitted during March 1, 2015 to September 30, 2016 at MYH and MGM Medical College Hospital, Indore were examined for study purpose. The patients of sickle cell disease were selected on the basis of inclusion and exclusion criteria. All patients enrolled were submitted for a clinical examination and later a laboratory work up. Results were analysed using Student’s t-test (two tailed, independent) and Pearson’s correlation test to assess any possible correlation of elevated pulse pressure with different biomarkers of haemolysis, proteinuria and chronic kidney disease.
RESULTS
In this study, we found that the elevated pulse pressure had a positive correlation with the presence of protienuria, chronic kidney disease and elevated serum creatinine in patients with sickle cell disease. In addition it also had a positive correlation with raised liver enzymes, reticulocyte count and systolic blood pressure suggesting a positive correlation with haemolysis and liver disease.
CONCLUSION
Elevated pulse pressure is closely linked to haemolysis, proteinuria and chronic kidney disease in SCD patients and further studies may be warranted to prove it as an independent predictor.
