Chandra Prakash Thakur, Kallol Bhattacharjee, Dwijen Das
BACKGROUND Coronary artery disease remains the dominating cause of death in the world. Despite understanding and controlling the known risk factors for coronary artery disease, it remains the worldwide epidemic. This raises the possibility of the presence of unknown or underestimated risk factors. The role of uric acid as a prognostic factor in patients with acute coronary syndrome is controversial. The aim of the present study is to estimate serum uric acid levels in acute coronary syndrome and its correlation with Killip’s classification of heart failure and in hospital mortality. MATERIALS AND METHODS A total of 100 patients with acute coronary syndrome meeting the inclusion and exclusion criteria, with an equal number of age and sex matched controls were selected for study during the period 1st July 2016 - 30th June 2017. Serum uric acid level was estimated on day 0 and 7 of acute coronary syndrome. RESULTS A statistically significant higher level of serum uric acid concentration in patients of acute coronary syndrome (5.80 ± 1.53) was observed on the day of admission as compared to controls (3.8 ± 0.85). There was no statistically significant difference observed in relation with diabetes and hypertensive status and gender. Higher serum uric acid (>7 mg/dl) level along with higher Killip’s class (III, IV) was associated with higher mortality and major adverse cardiac events. CONCLUSION It is concluded from the present study that serum uric acid levels were higher in patients of ACS as compared to healthy controls. Patients with elevated serum uric acid levels belonged to higher Killip’s classification and had higher mortality. It can be inferred from this study that serum uric acid can be regarded as an inexpensive independent risk factor and prognostic marker for assessing short term mortality in patients with ACS.
