M. Devojee1, G. Rajeshwari2, K. Jagan Mohan Rao3, M. P. Akarsh4
Xanthelasmas of the upper gastrointestinal tract are uncommon endoscopic lesions that may cause diagnostic confusion in patients at risk for neoplasia. Many reports about Gastric Xanthomas have shown its frequency of 0.018%-0.8%. Although the clinical significance of gastric xanthelasmas is unclear, they are important lesions because they may be confused with malignant lesions. Xanthelasma is more frequent in women and its incidence increases with age. Xanthomas are mostly diagnosed in the lamina propria of the stomach, mainly in the antrum and pyloric region. Grossly, they appear as small round to oval shaped well circumscribed yellow white intramucosal nodules or plaques. Histologically, they consist of loosely organized aggregates of foamy histiocytes in the lamina propria. There are few reports of gastric xanthomas in the literature. On endoscopy it may mimic malignancy and inexperienced clinicians may be confused. On histopathology foamy cells may sometimes resembles signet ring cells as seen in malignancy. So targeted biopsy and histopathological examination is required for such lesions.
