Department of Biophysics, Selcuk University, Konya, Turkey
Research Article
The Effects of 17 - Beta Estradiol on the Male Rat's Cardiovascular System
Author(s): Duygu Dursunoglu*, Ender Erdogan and Murat Ayaz
Estrogen is known to have cardio protective effects in women. However, there are contradictory data about the cardiovascular effects of estrogen in men in the literature. The aim of this study is to investigate the effects of castration and estrogen treatment after castration on the heart tissues of male rats by immunohistochemically detecting various molecules (growth factors and receptors, chemokine’s and sex hormone receptors) that play a role in cardiovascular diseases. For this purpose, three experimental groups consisting of 21 male rats were formed in the study: control (C), castrated (M -) and post - castration 17 - beta estradiol (E2) treatment (MX) groups. The heart tissues obtained from all groups stained immunohistochemically with primer antibodies for transforming growth factor - β1 (TGF β1), transforming growth factor - β receptor I (TGF βRI), t.. View More»
