Department of Hematology, Post-Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
Research Article
Analysis of Monocyte Distribution Width (MDW) as a Biomarker for early Sepsis Detection in a Tertiary Care Hospital in North India
Author(s): Shano Naseem, Neelam Varma*, Ishwar Bihana, Praveen Sharma, Brijesh Verma, Sanjeev Kumar, Navneet Sharma, Pallab Ray, Shivaprakash M Rudramurthy, RK Ratho, Sandhya Bastian and Elena Sukhacheva
Introduction
Early sepsis identification is vital to give specific treatment. Biomarkers for Sepsis have been studied however, none are specific. This study, Monocyte Distribution Width (MDW) was evaluated as a biomarker for sepsis and infection detection.
Methods
356 adult patients presented to the emergency department with suspected infection or Sepsis, in whom a complete blood count with differential leucocyte count was performed, were included in the study. Patients were classified into diagnostic groups with sepsis - 2 and sepsis - 3 criteria. MDW was evaluated on the Beckman Coulter DxH 900 hematology analyser. MedCalc was used for statistical analysis to calculate Area Under the Curve (AUC), Positive Predictive Value (PPV), Negative Predictive Value (NPV), sensitivity, specificity, and the positive and negative likelihoo.. View More»
