Department of Pathology and Paediatrics, Lady Hardinge Medical College and Associated Hospital, New Delhi, India
Research Article
Cytokine Profile of Type 1 and Type 2 T Helper Cells in Children with Acute Immune Thrombocytopenia
Author(s): Bhaskar Vanita*, Nangia Anita, Sharma Sunita, Chandra Jagdish and Seth Anju*
BACKGROUND
Immune thrombocytopenia is an autoimmune disorder characterized by low circulating platelet count caused by destruction of antibody sensitized platelets in reticuloendothelial system. It can be primary or in association with other disorders. It was recently reported that dysfunctional cellular immunity may play an important role in pathophysiology of ITP.
AIM
To study pretreatment and posttreatment cytokine profile of Th1 (IL - 2, IFNy) and Th2 (IL-4, IL-10) T cells in children with acute immune thrombocytopenia.
SETTINGS AND DESIGN
Interventional and observational study.
MATERIALS AND METHODS
A total of 30 patients were evaluated in the study. The tests performed included are complete haemogram including platelet count, peripheral smear .. View More»
