Department of Medical Biochemistry, Delta State University, PMB 1, Abraka, Nigeria
Review Article
Testicular Toxicity of the Concurrent Administration of Cadmium And Arsenic Through The Food Chain
Author(s): Theresa Ezedom* and Samuel Ogheneovo Asagba
Background
This study examined the effects of Cadmium (Cd) and Arsenic (As) through a controlled food chain on testes antioxidant status, protein concentration and expression of mRNA of Bax and Bcl - 2 genes.
Method
Catfish exposed to both metals at a concentration of 0.4 mg/ metal / 100 mL for 1 month served as source of protein for the experimental diet which rats were exposed to for 1 and 3 months. The metal burden on the feed and testes, activities of antioxidant enzymes, mRNA expression of Bax and Bcl - 2 in the testes were then carried out using standard procedures.
Result
The activities of the antioxidants enzymes and reduced glutathione (GSH) were significantly (p < 0.05) decreased after 3 months. Testes total protein and MDA levels were significantly (p < 0.05) increased.. View More»
